News brief
Stephanie Soucheray, MA
Topics
COVID-19
Nature has published a large study showing that text message reminders to receive a COVID-19 booster worked to increase vaccine uptake, but that offering free rides to pharmacies did not.
The study was based on outcomes seen among 3.66 million CVS Pharmacy patients in the United States who were offered free round-trip Lyft rides via text to CVS Pharmacies for vaccination appointments andreceived seven differentsets of behaviorally informed vaccine reminder messages.
Though millions of Americans took the initial series of COVID-19 vaccines, subsequent booster doses have been less popular. In the fall of 2022 and 2023, less than 20% of Americans received bivalent boosters, the authors said.
"This raises the question of how COVID-19 booster vaccination can be increased," the authors said. "Although vaccine mandates are effective, they are not always popular or feasible, Moreover, in the United States, cash incentives for vaccination have proven surprisinglyineffective."
Text messages resulted in additional 30,000 vaccinations
Text messages and removing transportation hurdles to vaccination appointments were two methods suggested as possible ways to increase booster uptake. The megastudy, conducted in the autumn of 2022, looked at multiple interventions to increase vaccine update, and relied on CVS vaccine records to account for vaccine update in the 30 days post-intervention. Free Lyft rides and a series of seven text messages, all meant to convey to patients that a vaccine was ‘recommended’ and ‘waiting for you,’ were tested.
They found text messages increased the 30-day COVID-19 booster uptake by 21% (1.05 percentage points) and spilled over to increase 30-day influenza vaccinations by 8% (0.34 percentage points), resulting in additional 33,864 COVID-19 booster vaccinations and 10,756 flu vaccinations. But when the messages included the free Lyft ride offer, no increase in uptake from the baseline message was observed.
These extra vaccinations probably prevented an estimated 1,857 infections.
"Because COVID-19 booster vaccinations reduce infections by at least 43% compared with individuals who received their last monovalent COVID-19 dose at least 8 months before, these extra vaccinations probably prevented an estimated 1,857 infections," the authors concluded.
News brief Topics Antimicrobial Stewardship Gonorrhea CARB-X today announced an award of $1 million to Prompt Diagnostics LLC to develop a portable, rapid diagnostic test for antibiotic-resistant gonorrhea. The money will help the company further develop its portable, cartridge-based polymerase chain reaction (PCR) platform, which can detect multiple pathogenic bacteria targets and identify mutations that confer antibiotic resistance. CARB-X (Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator) wants Prompt to focus on demonstrating the feasibility of rapidly detecting Neisseria gonorrhoeae and reliably characterizing resistance to ceftriaxone, which could enable more effective treatment management and promote antimicrobial stewardship. Ceftriaxone is the recommended first-line treatment, and last remaining effective antibiotic, for gonorrhea, but resistance is growing. An estimated 82 million gonorrhea infections were reported globally in 2020. "Prompt's technology has the potential to efficiently detect the presence of ceftriaxone-resistant gonorrhea, which poses a growing and significant global public health risk," Erin Duffy, PhD, R&D Chief of CARB-X, said in apress release. "Rapid, sophisticated diagnostics are essential to addressing drug-resistant bacterial infections globally, as they detect infections as early as possible while also directing healthcare providers to the most appropriate treatment." The low-cost test could be particularly useful in low- and middle-income countries, where rates of gonorrhea, and the burden of resistance, is higher and access to secondary healthcare facilities is limited. Duffy added that CARB-X is partnering with Prompt to"better understand the capabilities of their PCR platform and how it could support decentralized rapid ID and susceptibility testing for all of the major classes of antibiotics."A growing public health risk
News brief Lisa Schnirring Topics Mpox Drug regulators in the Democratic Republic of Congo (DRC) have approved the emergency use of two mpox vaccines to help curb a surge in cases involving a novel clade 1 strain, Reuters reported today, based on documents and sources involved in the process. The vaccines include Jynneos, made by Bavarian Nordic, and LC16, made by KM Biologics in Japan, where it is stockpiled for bioterrorism countermeasure purposes. Bavarian Nordic officials confirmed to Reuters that the DRC had approved emergency use, and a KM Biologics source told the news agency that there was potential supply of the vaccine. Unlike countries battling the global clade 2 mpox, African counties have never had access to vaccines or treatments. Gavi, the Vaccine Alliance, told Reuters that it is ready to facilitate vaccine donations from the United States and Japan. The group is unable to buy vaccine supplies for lower income countries until specific vaccines are prequalified by the World Health Organization (WHO). In a recent update, the WHO said the clade 1 outbreak continues to expand in the DRC, with the first case recently detected in North Kivu province, pushing the number of affected provinces to 23 of 26. The virus is spreading through various forms of contact, including sexual and household..jpg "Reminders—but not free rides—boost COVID-19 booster uptake (1)")
News brief Stephanie Soucheray, MA Topics Respiratory Syncytial Virus (RSV) Yesterday Moderna reported that its respiratory syncytial virus (RSV) vaccine, mResvia, showed only 50% efficacy in preventing the illness after 18 months. The results are disappointing compared to the 81% efficacy seen at 3.7 months. Moderna’s vaccine also underperformed compared to GlaxoSmithKlein’s vaccine, Arexvy, which was 68% effective over 23.3 months in a clinical trial. Trials have shown Pfizer's Abrysvo to be 78% effective after 16.4 months. The drugmaker announced the findings late yesterday afternoon at a meeting of the Centers for Disease Control and Prevention's (CDC's) Advisory Committee on Immunization Practices (ACIP). Last month the Food and Drug Administration (FDA) approved the Moderna vaccine for use in older adults, making it the second approved RSV vaccine for adults 60 years and older. ACIP currently recommends all US adults 75 and older receive a single RSV vaccine, and that people ages 60 to 74 also receive a dose of the vaccine. According to the CDC, 60,000 to 160,000 older adults each year are hospitalized in the United States due to RSV. Currently the CDC and ACIP are weighing age recommendations for approved RSV vaccines given concerns about the risk of Guillain-Barre syndrome (GBS) following RSV vaccination.
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This week's top reads
- CDC data show uptick in COVID-19 cases, low flu activity COVID test positivity, emergency department visits, hospitalizations, and deaths are are on the rise, but remain at low levels. Chris Dall
- USDA confirms more H5N1 detections in dairy herds and cats The latest H5N1 confirmations in cats involved animals from Texas and Minnesota. Lisa Schnirring
- CDC panel revises RSV vaccine recommendations for adults The new recommendations are easier to navigate in clinical settings and focus on older age groups who benefit most. Lisa Schnirring
- US sees more signs of possible COVID-19 surge Cases are tracking upwards from the lowest levels of the pandemic, most notably in the West and South. Lisa Schnirring
- Cannabis use linked to worse COVID-19 outcomes Cannabis use was significantly associated with increased risk of hospitalization. Stephanie Soucheray
- China reports another fatal H5N6 avian flu case Officials didn't say how the man contracted the virus, but most past cases involved contact with poultry or poultry environments. Lisa Schnirring
- Scientists expand H5N1 testing in dairy products, launch human serology study The FDA will sample more retail products across different regions, and a Michigan-led study serology study is underway in workers from affected farms. Lisa Schnirring
- Latest XBB COVID-19 vaccine offers protection against hospitalization, deaths Compared to those who had not received an updated XBB vaccine, recipients had 62% protection against COVID-19 hospitalization. Stephanie Soucheray
- CDC issues alert for dengue in the US The Americas region has seen a record surge in activity, as travel-linked cases rise and sporadic local cases reported from Florida. Lisa Schnirring
- Experiments show H5N1 risk to dairy cows not exclusive to subtype infecting US herds Researchers' other tests found no antibodies in cows in German regions affected by the virus or evidence of virus in milk samples. Lisa Schnirring
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